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Important sites for Clinical research and Clinical trials

first site 

http://www.sign.ac.uk/guidelines/published/index.html#CHD 

contain all disease and last trials for this disease 

second site 

http://summaries.cochrane.org/

http://www.cochrane.org/

3rd site 

http://www.lexi.com/search/?cx=002772095352357491926%3A_4b6riqnx68&cof=FORID%3A10%3BNB%3A1&ie=UTF-8&sa=Search&q=captopril

4rd 

http://www.ncbi.nlm.nih.gov/pubmed/clinical

this the most site contain newest trials 

http://www.guideline.gov/search/advanced-search.aspx

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Induction of labour syntocinon

Composition :synthetic oxytocin 

Properties :

syntocinon contains synthetically prepared oxytocin 

the pharmacological and clinical action of syntocinon are identical with those of natural oxytocin ,but it is completely free from vasopressin 

syntocinon stimulates rhythmic contractions of uterus , inreases the frequency and amplitude of existing contractions , and improves the tone of uterine musculature without preventing the relaxation between contractions which is of primary importance in the avoidance of foetal asphyxia .

AS the pressor and antidiuretic effect is very low 

it may also used in gestosis (eclampsia , nephropathy) .

Indication :

1- induction of labour at term in the absence of uterine contraction :
a.postmaturity

b.premature rupture of the membrane 

c.foetal distress 

d.toxaemia of pregnancy.

2-primary and secondary uterine inertia.

3-caesarean section.

4-promotion of lactation and prevention of breast engorgement .

contraindication 

cephalopelvic disproportion .

over distention of uterus :multiparity,twin birth ,hydramnion

abnormal presentation 

hypertonic contractions

previous caesarean section   or other uterine operation 

Dosage and administration 

indution of labour 

i.v drip infusion of 1 unit in 100 ml of 5 %glucose solution at a rate of 8 to 40 drops per minute or more if required or 0.5 to 2 units by i.m injection repeatable every 30 min to 60 minutes 

inadequate uterine effect 

i.v drip infusion  as above or 0.25 to 1 unit bt i.m injection 

this dose after latent period of 3 to 10 minutes exerts its effect  for 30 to 60 minutes (may be repeated ) 

caesarean section 

5 units of syntocinon intramurally after extraction of baby .

dosage form : mostly ampoules